✔ 100% Authentic Product
👁️ Currently Viewing 368
Targaba 5 Tablet 1 Strip
Targaba is recommended for the treatment of various types of neuropathic pain, including:
- Neuropathic pain in general
- Diabetic peripheral neuropathy (DPNP)
- Postherpetic neuralgia (PHN)
- Peripheral neuropathic pain (PNP)
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Cash on Delivery - All over Bangladesh
Regular Delivery - 8-12 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
✅ Description:
Mirogabalin, a derivative of gamma-aminobutyric acid (GABA), works by selectively binding to the α2δ subunits of voltage-gated calcium channels. This action reduces calcium influx in neurons, limiting the release of excitatory neurotransmitters. By suppressing neurotransmission, it helps diminish the hyperactivity of central nervous system (CNS) neurons associated with neuropathic pain.
Absorption: Rapid after oral intake; peak plasma levels reached within 0.5 to 1.5 hours.
Distribution: Low protein binding (~25%); volume of distribution: 64–88 L.
Metabolism & Excretion: Eliminated mainly unchanged via renal excretion (61–72%). Minor hepatic metabolism via UGT enzymes. Mean half-life: 2–4.9 hours. About 99% is excreted in urine, and 1% via feces.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Precautions & Warnings
- May impair coordination and alertness—avoid driving or operating machinery.
- Use cautiously in elderly patients due to increased risk of falls and cognitive effects.
- Weight gain and visual disturbances may occur.
- Adjust the dose in patients with renal impairment.
- Avoid alcohol and consult a physician before combining with other medications.
- Discontinue immediately if allergic symptoms appear.
✔️ Dosage & Administration
- Adults: Start with 5 mg twice daily, increasing by 5 mg per week to a maximum of 15 mg twice daily, depending on age and symptom severity.
- Pediatrics: Safety and efficacy in children and adolescents have not been established.
- Hepatic Impairment: Single 15 mg doses are tolerated in mild-to-moderate cases; data unavailable for severe impairment.
Renal Impairment:
- Mild: Start with 5 mg twice daily, titrate to max 10 mg twice daily.
- Moderate: Begin with 2.5 mg twice daily, titrate to max 7.5 mg twice daily.
- Severe: Start with 2.5 mg once daily, increase gradually to 7.5 mg once daily.
✔️ Side Effects
- Drowsiness
- Dizziness
- Swelling (edema)
- Weight gain
Serious but rare symptoms (discontinue and consult a doctor immediately):
Impaired consciousness, fainting, or somnolence
Nausea, vomiting, appetite loss, jaundice (signs of liver dysfunction)
Visual disturbances such as blurred or double vision
✔️ Drug Interactions
With Medicines: Co-administration with Cimetidine or Probenecid may elevate Targaba levels. Combined use with Lorazepam may enhance CNS depression. Mirogabalin is a substrate of OAT1, OAT3, OCT2, MATE1, MATE2-K, and UGT enzymes. It does not inhibit or induce major CYP enzymes or drug transporters.
With Food/Alcohol: Food has no significant impact on absorption. Avoid alcohol, as it may intensify sedation and motor impairment.
✔️ Contraindications
Hypersensitivity to Mirogabalin.
Known cases of mild to moderate hepatic or renal impairment (use with caution).
✔️ Use During Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the risk.
Animal studies indicate placental transfer and secretion in breast milk.
Weigh the benefits of breastfeeding against the possible risks before use in nursing mothers.
✔️ Storage
Store below 30°C in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
