Targaba 5 Tablet 1 Strip

✔️ Precautions & Warnings

• May impair coordination and alertness—avoid driving or operating machinery.
• Use cautiously in elderly patients due to increased risk of falls and cognitive effects.
• Weight gain and visual disturbances may occur.
• Adjust the dose in patients with renal impairment.
• Avoid alcohol and consult a physician before combining with other medications.
• Discontinue immediately if allergic symptoms appear.

✔️ Dosage & Administration

• Adults: Start with 5 mg twice daily, increasing by 5 mg per week to a maximum of 15 mg twice daily, depending on age and symptom severity.
• Pediatrics: Safety and efficacy in children and adolescents have not been established.
• Hepatic Impairment: Single 15 mg doses are tolerated in mild-to-moderate cases; data unavailable for severe impairment.

Renal Impairment:

• Mild: Start with 5 mg twice daily, titrate to max 10 mg twice daily.
• Moderate: Begin with 2.5 mg twice daily, titrate to max 7.5 mg twice daily.
• Severe: Start with 2.5 mg once daily, increase gradually to 7.5 mg once daily.

✔️ Side Effects

• Drowsiness
• Dizziness
• Swelling (edema)
• Weight gain

Serious but rare symptoms (discontinue and consult a doctor immediately):

Impaired consciousness, fainting, or somnolence

Nausea, vomiting, appetite loss, jaundice (signs of liver dysfunction)

Visual disturbances such as blurred or double vision

✔️ Drug Interactions

With Medicines: Co-administration with Cimetidine or Probenecid may elevate Targaba levels. Combined use with Lorazepam may enhance CNS depression. Mirogabalin is a substrate of OAT1, OAT3, OCT2, MATE1, MATE2-K, and UGT enzymes. It does not inhibit or induce major CYP enzymes or drug transporters.

With Food/Alcohol: Food has no significant impact on absorption. Avoid alcohol, as it may intensify sedation and motor impairment.

✔️ Contraindications

Hypersensitivity to Mirogabalin.

Known cases of mild to moderate hepatic or renal impairment (use with caution).

✔️ Use During Pregnancy & Lactation

Use during pregnancy only if the potential benefit justifies the risk.

Animal studies indicate placental transfer and secretion in breast milk.

Weigh the benefits of breastfeeding against the possible risks before use in nursing mothers.

✔️ Storage

Store below 30°C in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children.